Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Potassium Channel - DMP 543

DMP 543

CAS No. 160588-45-4

DMP 543( XR-543 | XR 543 | DMP-543 )

Catalog No. M12308 CAS No. 160588-45-4

A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 58 Get Quote
10MG 87 Get Quote
25MG 205 Get Quote
50MG 335 Get Quote
100MG 500 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    DMP 543
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
  • Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued.
  • In Vitro
    DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM.
  • In Vivo
    ——
  • Synonyms
    XR-543 | XR 543 | DMP-543
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    160588-45-4
  • Formula Weight
    412.44
  • Molecular Formula
    C26H18F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (242.47 mM)
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
  • Chemical Name
    10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22. 2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. 3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22. 4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Linopirdine dihydroc...

    Linopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).

  • BeKm 1

    Potent and selective KV11.1 (hERG) channel blocker. Selective for KV11.1 over a panel of 14 other potassium channels. Dose-dependently prolongs QTc interval in isolated rabbit heart.

  • TASK-1-IN-1

    TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) with an IC50 of 148 nM, and exhibits a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM. TASK-1-IN-1 also demonstrates anticancer effects.

Sign In Join Free